Comment on "Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery".
نویسنده
چکیده
Tyzio et al. (Reports, 15 December 2006, p. 1788) reported that maternal oxytocin triggers a transient excitatory-to-inhibitory switch of gamma-aminobutyric acid (GABA) signaling during labor, thus protecting the fetal rat brain from anoxic injury. However, a body of evidence supports the possibility that oxytocin is released from the fetal pituitary during delivery, not only from the mother, particularly under conditions of hypoxic stress.
منابع مشابه
Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery.
We report a signaling mechanism in rats between mother and fetus aimed at preparing fetal neurons for delivery. In immature neurons, gamma-aminobutyric acid (GABA) is the primary excitatory neurotransmitter. We found that, shortly before delivery, there is a transient reduction in the intracellular chloride concentration and an excitatory-to-inhibitory switch of GABA actions. These events were ...
متن کاملRoman Tyzio , Delivery Switch in GABA Signaling in the Fetal Brain During Maternal Oxytocin Triggers a Transient Inhibitory
www.sciencemag.org (this information is current as of December 15, 2006 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/314/5806/1788 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/314/5806/1788/DC1 can be f...
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عنوان ژورنال:
- Science
دوره 317 5835 شماره
صفحات -
تاریخ انتشار 2007